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Case Reports
. 2010 Jan;2(1):39-41.

Bilateral proliferating Brenner tumor of the ovary associated with recurrent urothelial carcinoma of the urinary bladder

Sonia Ziadi  1 , Mounir Trimeche, Faten Hammedi, Samir Hidar, Baddredine Sriha, Sarra Mestiri, Sadok Korbi
Affiliations
Case Reports

Bilateral proliferating Brenner tumor of the ovary associated with recurrent urothelial carcinoma of the urinary bladder

Sonia Ziadi et al. N Am J Med Sci. 2010 Jan.

Abstract

Context: Brenner tumors of ovary are relatively uncommon neoplasm. Most of them are benign and less than 5% are proliferating or borderline. The association between Brenner tumor of the ovary and papillary urothelial carcinoma of bladder is extremely rare.

Case report: We describe an unusual case of proliferating bilateral Brenner tumor of the ovary with a highly recurrent low-grade papillary urothelial carcinoma of bladder.

Conclusion: The immunohistopathological similarities of ovarian and bladder tumors and their association in the current case, may be coincidental but may reflect a common initiating event inducing similar pathogenesis changes in the epithelium of both organs. More cases are needed to be reported to better understand this association.

Keywords: Brenner tumor; ovary; urinary bladder; urothelial carcinoma.

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Figures

Fig. 1
Fig. 1
Macroscopy of the right ovarian tumor: a papillary, polypoid component protrudes into a cystic space.
Fig. 2
Fig. 2
Proliferating Brenner tumor of the right ovary: a and b: Hematoxylin and eosin staining showing the papillomatous, without infiltrating configuration with low grade cytological features (Magnification ×40 and ×200); c and d: Immunohistochemistry showing positivity of the tumor cells for cytokeratin 7 (Magnification ×40 and ×200).
Fig. 3
Fig. 3
Urothelial carcinoma of the bladder: a and b: Hematoxylin and eosin staining showing a papillomatous urothelial cell proliferation with low grade cytological features (Magnification ×40); c and d: Immunohistochemistry showing positivity of the tumor cells for cytokeratin 7 (Magnification ×40 and ×200).
See this image and copyright information in PMC

References

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