Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Aug;26(8):1052-7.
doi: 10.1038/eye.2012.86. Epub 2012 May 25.

Macular pigment optical density in wet age-related macular degeneration among Indians

R Raman  1 , S Biswas, K Vaitheeswaran, T Sharma
Affiliations

Macular pigment optical density in wet age-related macular degeneration among Indians

R Raman et al. Eye (Lond). 2012 Aug.

Abstract

Purpose: To estimate the value of macular pigment optical density (MPOD) in adult south Indian population with wet age-related macular degeneration (AMD).

Methods: A total of 33 patients with wet AMD and 29 age-matched controls >50 years of age underwent MPOD measurement with the macular densitometer. The patients were also tested for their dietary intake of carotenoids, smoking history, and lifetime UV exposure.

Results: The mean MPOD values in the Indian population with wet AMD was 0.23 (95% CI: 0.18-0.29) vs control was 0.43 (95% CI: 0.37-0.49), P<0.0001, at 0.5° eccentricity. Ex-smokers had a lower MPOD than non-smokers (0.16 (0.09-0.23) vs 0.28 (0.22-0.34), P=0.026) and the lowest level of carotenoids intake had 48% lower MPOD than the highest level (0.14 (0.08-0.21) vs 0.33 (0.24-0.43), P=0.012). There was no significant age-related decline or gender variation in MPOD.

Conclusion: This study establishes the MPOD in adult Indian population with wet AMD, with a lack of macular pigment in association with wet AMD.

PubMed Disclaimer

Figures

Figure 1
Figure 1
MPOD among subjects with and without AMD. AMD: Age-related macular degeneration, MPOD: Macular pigment optical density.
Figure 2
Figure 2
Relationship between MPOD and pack years of smoking. MPOD: Macular pigment optical density.
Figure 3
Figure 3
Relationship between MPOD and dietary carotenoids. MPOD: Macular pigment optical density.
Figure 4
Figure 4
Bland–Altman plot for MPOD showing difference between measurements by two observers versus the average MPOD of the two observers.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Krishnan T, Ravindran RD, Murthy GV, Vashist P, Fitzpatrick KE, Thulasiraj RD, et al. Prevalence of early and late age-related macular degeneration in India: the INDEYE study. Invest Ophthalmol Vis Sci. 2010;51:701–707. - PMC - PubMed
    1. Krishnaiah S, Das T, Nirmalan PK, Nutheti R, Shamanna BR, Rao GN, et al. Risk factors for age-related macular degeneration: findings from the Andhra Pradesh eye disease study in South India. Invest Ophthalmol Vis Sci. 2005;46:4442–4449. - PubMed
    1. Bressler NM. Early detection and treatment of neovascular age related macular degeneration. J Am Board Fam Pract. 2002;15:142–152. - PubMed
    1. Rajan SI, Sarma PS, Mishra US. Demography of Indian aging, 2001–2051. J Aging Soc Policy. 2003;15:11–30. - PubMed
    1. Vingerling JR, Dielemans I, Hofman A, Grobbee DE, Hijmering M, Kramer CF, et al. The prevalence of age-related maculopathy in the Rotterdam Study. Ophthalmol. 1995;102:205–210. - PubMed