Oxygenated lipids: a mode to WiPE out inflammation?
- PMID: 22633456
- DOI: 10.1016/j.immuni.2012.05.006
Oxygenated lipids: a mode to WiPE out inflammation?
Abstract
The immunologically silent clearance of apoptotic cells is crucial for maintaining self-tolerance. In this issue of Immunity, Uderhardt et al. (2012) reveal a mechanism by which lipid oxidation by tissue resident macrophages could inhibit the engulfment of apoptotic cells by inflammatory monocytes.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance.Immunity. 2012 May 25;36(5):834-46. doi: 10.1016/j.immuni.2012.03.010. Epub 2012 Apr 12. Immunity. 2012. PMID: 22503541
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