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Review
. 2012 May 25;36(5):705-16.
doi: 10.1016/j.immuni.2012.05.008.

The chemokine superfamily revisited

Albert Zlotnik  1 , Osamu Yoshie
Affiliations
Review

The chemokine superfamily revisited

Albert Zlotnik et al. Immunity. .

Abstract

The chemokine superfamily consists of a large number of ligands and receptors. At first glance, this family appears redundant and their ligand-receptor relationships promiscuous, making its study challenging. However, analyzing this family from the evolutionary perspective greatly simplifies understanding both the organization and function of this apparently complex system. In particular, the functions of a subgroup of chemokines (designated homeostatic chemokines) have played pivotal roles in advancing our understanding of the organization and function of the cellular networks that shape the immune system. Here, we update the full scope of the human and mouse chemokine superfamilies and their relationships and summarize several important roles that homeostatic chemokines play in the immune system.

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Figures

Figure 1
Figure 1
Chromosomal map of the human chemokine and chemokine receptor genes. The full set of human chromosomes is shown with the locations of the chemokine and chemokine receptor genes indicated as follows: chemokines (white) and chemokine receptors (gray).
See this image and copyright information in PMC

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