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Review
. 2012 Nov;14(14):1284-92.
doi: 10.1016/j.micinf.2012.05.011. Epub 2012 May 24.

Extracellular NAD(+): a danger signal hindering regulatory T cells

Sahil Adriouch  1 , Friedrich Haag, Olivier Boyer, Michel Seman, Friedrich Koch-Nolte
Affiliations
Free article
Review

Extracellular NAD(+): a danger signal hindering regulatory T cells

Sahil Adriouch et al. Microbes Infect. 2012 Nov.
Free article

Abstract

Endogenous danger signals released during cell damage contribute to alert the immune system. Typically, their release results in the activation and maturation of innate immune cells, and the production of pro-inflammatory cytokines. In addition, extracellular NAD(+) stimulates immune responses by hindering regulatory T cells (Tregs), and could, therefore, represent the prototype of a new category of danger signals.

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