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Comparative Study
. 1990 Dec 11;18(23):6927-33.
doi: 10.1093/nar/18.23.6927.

Detection of a specific mitochondrial DNA deletion in tissues of older humans

G A Cortopassi  1 , N Arnheim
Affiliations
Free PMC article
Comparative Study

Detection of a specific mitochondrial DNA deletion in tissues of older humans

G A Cortopassi et al. Nucleic Acids Res. .
Free PMC article

Abstract

Using PCR, we found that normal heart muscle and brain from adult human individuals contain low levels of a specific mitochondrial DNA deletion, previously found only in patients affected with certain types of neuromuscular disease. This deletion was not observed in fetal heart or brain. Experimental tests support the idea that the deletion exists in vivo in adult mitochondria and is not an in vitro artifact of PCR. Our data provide direct experimental support for the idea that accumulation of mitochondrial DNA deletions may be important in aging.

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References

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