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. 2012 Jun;139(6):395-406.
doi: 10.1085/jgp.201210797.

Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial proteome design: from molecular identity to pathophysiological regulation

Jun Zhang  1 , Amanda Lin, Jared Powers, Maggie P Lam, Christopher Lotz, David Liem, Edward Lau, Ding Wang, Ning Deng, Paavo Korge, Nobel C Zong, Hua Cai, James Weiss, Peipei Ping
Affiliations

Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial proteome design: from molecular identity to pathophysiological regulation

Jun Zhang et al. J Gen Physiol. 2012 Jun.
No abstract available

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Figures

Figure 1.
Figure 1.
Milestones in mitochondrial research. Representative milestones in mitochondrial research, including mitochondrial function, structure, and mitochondrial medicine, are listed in a chronological sequence (1890–current). Our apologies to those not represented in this timeline.
Figure 2.
Figure 2.
Schematic overview of mitochondrial subproteomes in health and disease. This figure contextualizes mitochondrial proteomes to their biological pathways and the consequences of the proteome compositions to clinical phenotypes. Mitochondrial pathways responsible for fundamental cellular functions within the cell, including OXPHOS, TCA cycle, β oxidation, apoptosis, proteolysis, redox, protein import, and calcium regulation, are detailed. Other mitochondrial functions related to specific cell types are not listed. Within each mitochondrial subproteome, the first number represents the total number of proteins associated with its function (the number of proteins was collected in our previous study; Zhang et al., 2008); the next number inside the parentheses (*) signifies the portion of the total proteins in this particular subproteome reported to be implicated in metabolic diseases.
Figure 3.
Figure 3.
Current state-of-the-art technology platform to characterize mitochondrial proteomes. This figure depicts the current technology platform used to characterize mitochondrial proteomes from model systems, including mitochondrial preparation, protein/peptide fractionations, MS instrumentation, protein identification/PTM analyses, protein quantification, and data validation.
See this image and copyright information in PMC

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