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. 2012 Jul;5(3):187-201.
doi: 10.2174/1874471011205030187.

Scandium-44: benefits of a long-lived PET radionuclide available from the (44)Ti/(44)Sc generator system

F Roesch  1
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Scandium-44: benefits of a long-lived PET radionuclide available from the (44)Ti/(44)Sc generator system

F Roesch. Curr Radiopharm. 2012 Jul.

Abstract

(44)Ti/(44)Sc radionuclide generators are of interest for molecular imaging. The 3.97 hours half-life of (44)Sc and its high positron branching of 94.27% may stimulate the application of (44)Sc-labeled PET radiopharmaceuticals. This review describes the current status of (44)Ti production, (44)Ti/(44)Sc radionuclide generator development, post-processing of generator eluates towards medical application, identification of ligands adequate to Sc(III) co-ordination chemistry, proof-of-principle labeling of (44)Sc-DOTA-octreotides, investigation of in vitro and in vivo parameters, and initial applications for molecular imaging - both in small animals and humans.

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