Comment on

• Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load.

  West EE, Youngblood B, Tan WG, Jin HT, Araki K, Alexe G, Konieczny BT, Calpe S, Freeman GJ, Terhorst C, Haining WN, Ahmed R. West EE, et al. Immunity. 2011 Aug 26;35(2):285-98. doi: 10.1016/j.immuni.2011.05.017. Immunity. 2011. PMID: 21856186 Free PMC article.
• When the going gets tough, memory T cells check out.

  Hill A. Hill A. Immunity. 2011 Aug 26;35(2):158-60. doi: 10.1016/j.immuni.2011.08.006. Immunity. 2011. PMID: 21867925
• Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexes.

  Kumar R, Ferez M, Swamy M, Arechaga I, Rejas MT, Valpuesta JM, Schamel WW, Alarcon B, van Santen HM. Kumar R, et al. Immunity. 2011 Sep 23;35(3):375-87. doi: 10.1016/j.immuni.2011.08.010. Epub 2011 Sep 8. Immunity. 2011. PMID: 21903423
• Nanocluster formation: more with memory.

  Saito T. Saito T. Immunity. 2011 Sep 23;35(3):318-20. doi: 10.1016/j.immuni.2011.09.008. Immunity. 2011. PMID: 21943486
• Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes.

  Newell EW, Sigal N, Bendall SC, Nolan GP, Davis MM. Newell EW, et al. Immunity. 2012 Jan 27;36(1):142-52. doi: 10.1016/j.immuni.2012.01.002. Immunity. 2012. PMID: 22265676 Free PMC article.
• The numerology of T cell functional diversity.

  Haining WN. Haining WN. Immunity. 2012 Jan 27;36(1):10-2. doi: 10.1016/j.immuni.2012.01.006. Immunity. 2012. PMID: 22284416 Free PMC article.