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Case Reports
. 2012 Aug;56(8):4516-8.
doi: 10.1128/AAC.00234-12. Epub 2012 May 29.

In vivo emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli

Teresa Spanu  1 , Giulia De Angelis, Michela Cipriani, Barbara Pedruzzi, Tiziana D'Inzeo, Maria Adriana Cataldo, Gabriele Sganga, Evelina Tacconelli
Affiliations
Case Reports

In vivo emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli

Teresa Spanu et al. Antimicrob Agents Chemother. 2012 Aug.

Abstract

Although resistance to tigecycline has been reported in surveillance studies, very few reports have described the emergence of resistance in vivo. We report two cases of patients with infections due to SHV-12-producing Klebsiella pneumoniae and K. pneumoniae carbapenemase-3 (KPC-3)-producing Escherichia coli, which developed tigecycline resistance in vivo after treatment. The reported limited experience underlines the risk of occurrence of a tigecycline MIC increase under treatment pressure.

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References

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