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. 2012 Jun 25;51(26):6452-5.
doi: 10.1002/anie.201202383. Epub 2012 May 29.

Bidirectional photocontrol of peptide conformation with a bridged azobenzene derivative

Subhas Samanta  1 , Chuanguang Qin, Alan J Lough, G Andrew Woolley
Affiliations

Bidirectional photocontrol of peptide conformation with a bridged azobenzene derivative

Subhas Samanta et al. Angew Chem Int Ed Engl. .

Abstract

It goes both ways: A thiol-reactive cross-linker based on a bridged azobenzene derivative permits photoreversible control of peptide conformation on irradiation with violet (407 nm) and green (500-550 nm) light (see picture) through isomerization of the cross-linker. The large separation of the absorbance bands of the cis (yellow) and trans (red) isomers enables complete bidirectional photoswitching.

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