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Comment
. 2012 Jun 12;109(24):9230-1.
doi: 10.1073/pnas.1206645109. Epub 2012 May 29.

Fibrogenic cell reversion underlies fibrosis regression in liver

Scott Laurence Friedman  1
Affiliations
Comment

Fibrogenic cell reversion underlies fibrosis regression in liver

Scott Laurence Friedman. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Fates of activated hepatic stellate cells during fibrosis regression. After injury to the liver, stellate cell activation leads to fibrosis progression. Activation reflects the transdifferentiation from a quiescent vitamin A-rich cell to an activated stellate cell/myofibroblast, which expresses mitogenic receptors and is contractile with reduced vitamin A content. If injury is attenuated, fibrosis regression can occur, leading to either apoptosis of stellate cells or reversion to an inactivated state with restored features of quiescence. However, inactivated stellate cells still retain an intermediate phenotype, with enhanced capacity to respond to fibrogenic signals and reactivate on further injury.
See this image and copyright information in PMC

Comment on

  • Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis.
    Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, Iwaisako K, Moore-Morris T, Scott B, Tsukamoto H, Evans SM, Dillmann W, Glass CK, Brenner DA. Kisseleva T, et al. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9448-53. doi: 10.1073/pnas.1201840109. Epub 2012 May 7. Proc Natl Acad Sci U S A. 2012. PMID: 22566629 Free PMC article.

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