Review
doi: 10.1016/j.canep.2012.05.004.
Epub 2012 May 28.
miRNA-101: a potential target for tumor therapy
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- PMID: 22647681
- DOI: 10.1016/j.canep.2012.05.004
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Review
miRNA-101: a potential target for tumor therapy
Cancer Epidemiol.
2012 Dec.
Abstract
microRNAs are genomically encoded small non-coding RNAs that regulate genetic information by controlling stability or translation of mRNAs. Down-regulated expression of microRNA-101 (miRNA-101) has been found in a variety of cancers, and associated with the invasion and progression of malignancies. Recent advances in the understanding of miRNA-101 biogenesis, target recognition and participation in regulatory pathways demonstrate a role for miRNA-101 in tumorigenesis. miRNA-101 gene therapy is of great potentiality to be a new modality for treatment of cancers.
Copyright © 2012 Elsevier Ltd. All rights reserved.
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