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. 1979 Aug;25(2):565-68.
doi: 10.1128/iai.25.2.565-568.1979.

Depression of bovine monocyte chemotactic responses by bovine viral diarrhea virus

A T Ketelsen, D W Johnson, C C Muscoplat

Depression of bovine monocyte chemotactic responses by bovine viral diarrhea virus

A T Ketelsen et al. Infect Immun. 1979 Aug.

Abstract

Incubation of bovine peripheral blood monocytes with bovine viral diarrhea virus (either Singer or NY-1 strain) caused a consistent, statistically significant decrease in their random locomotion (no chemoattractant) and chemotaxis towards a chemotactic lymphokine. Chemotaxis was determined by a modification of the Boyden method. Incubation of bovine viral diarrhea virus with mononuclear cells depressed chemotaxis by a mean of 56% (P less than 0.0005). Heat-killed virus had no effect on monocyte motility. Data suggest that bovine viral diarrhea virus can rapidly suppress monocyte functions in vitro, but by unknown mechanisms, not by killing cells.

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