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. 2012 Aug;50(8):2793-5.
doi: 10.1128/JCM.00678-12. Epub 2012 May 30.

Multiclonal origin of macrolide-resistant Mycoplasma pneumoniae isolates as determined by multilocus variable-number tandem-repeat analysis

Yang Liu  1 , Xinye Ye, Hong Zhang, Xiaogang Xu, Minggui Wang
Affiliations

Multiclonal origin of macrolide-resistant Mycoplasma pneumoniae isolates as determined by multilocus variable-number tandem-repeat analysis

Yang Liu et al. J Clin Microbiol. 2012 Aug.

Abstract

There was a high percentage of macrolide resistance in Mycoplasma pneumoniae clinical isolates in China. The genetic relatedness of macrolide-resistant M. pneunomiae strains was investigated using the multilocus variable-number tandem-repeat assay (MLVA). Among 152 M. pneunomiae isolates, the 137 macrolide-resistant strains were clustered into 15 MLVA types, indicating that the high macrolide resistance rate in M. pneumoniae is a result of the dissemination of the multiple resistant clones.

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Figures

Fig 1
Fig 1
Minimal spanning tree of the MLVA profiles of 152 M. pneumoniae isolates. Each circle denotes a particular MLVA type (MT) indicated by a number corresponding to the genotype in parentheses. The size of the circle is proportional to the number of isolates belonging to the indicated MLVA genotype. Neighboring genotypes have the same distance.
See this image and copyright information in PMC

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