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Case Reports
. 2012 Jan;4(1):80-4.
doi: 10.1159/000337894. Epub 2012 Mar 30.

Autoimmunity-related granulomatous dermatitis in association with hepatitis

Grégory Szepetiuk  1 , Marianne Lesuisse, Gérald E Piérard, Pascale Quatresooz, Claudine Piérard-Franchimont
Affiliations
Case Reports

Autoimmunity-related granulomatous dermatitis in association with hepatitis

Grégory Szepetiuk et al. Case Rep Dermatol. 2012 Jan.

Abstract

Aim: Both interstitial granulomatous dermatitis (IGD) and palisaded neutrophilic granulomatous dermatitis (PNGD) are rare disorders typically associated with systemic autoimmune conditions. They probably represent different aspects of a disease spectrum encompassing the concept of autoimmunity-related granulomatous dermatitis (ARGD).

Case report: A 61-year-old woman presented with ARGD and autoimmune hepatitis. The clinical presentation suggested PNGD, while histopathology was consistent with IGD.

Discussion: The association of ARGD with autoimmune hepatitis is apparently a rare event. The present case shows that the clinicopathological correlation in ARGD does not always clearly fit with the classical presentations of IGD or PNGD.

Keywords: Autoimmunity; Granulomatous dermatitis; Hepatitis.

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Figures

Fig. 1
Fig. 1
Clinical presentation of ARGD. a Multiple papules in a plaque on the elbow. b Multiple papules grouped on the thenar region.
Fig. 2
Fig. 2
Immunohistopathology of an ARGD papule. a Perivascular clusters of CD3+ lymphocytes (×200). b Perivascular distribution of MAC387+ macrophages (×200). c Interstitial spread of CD68+ macrophages (×200). d Interstitial presence of factor XIIIa+ DD1 (×200).
See this image and copyright information in PMC

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