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. 2012:2012:105203.
doi: 10.1155/2012/105203. Epub 2012 May 9.

TCTP in development and cancer

Magdalena J Koziol  1 , John B Gurdon
Affiliations

TCTP in development and cancer

Magdalena J Koziol et al. Biochem Res Int. 2012.

Abstract

The translationally controlled tumor protein (TCTP) is highly conserved among animal species. It is widely expressed in many different tissues. It is involved in regulating many fundamental processes, such as cell proliferation and growth, apoptosis, pluripotency, and the cell cycle. Hence, it is not surprising that it is essential for normal development and, if misregulated, can lead to cancer. Provided herein is an overview of the diverse functions of TCTP, with a focus on development. Furthermore, we discuss possible ways by which TCTP misregulation or mutation could result in cancer.

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Figures

Figure 1
Figure 1
TCTP can activate the TOR pathway and promote cell proliferation and growth.
Figure 2
Figure 2
Pathways in which TCTP misregulation or mutations could cause cancer.
See this image and copyright information in PMC

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