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. 2012 Feb 28:2:19.
doi: 10.3389/fonc.2012.00019. eCollection 2012.

Family history of cancer in benign brain tumor subtypes versus gliomas

Quinn T Ostrom  1 , Christopher McCulloh, Yanwen Chen, Karen Devine, Yingli Wolinsky, Perica Davitkov, Sarah Robbins, Rajesh Cherukuri, Ashokkumar Patel, Rajnish Gupta, Mark Cohen, Jaime Vengoechea Barrios, Cathy Brewer, Cathy Schilero, Kathy Smolenski, Mary McGraw, Barbara Denk, Theresa Naska, Frances Laube, Ruth Steele, Dale Greene, Alison Kastl, Susan Bell, Dina Aziz, E A Chiocca, Christopher McPherson, Ronald Warnick, Gene H Barnett, Andrew E Sloan, Jill S Barnholtz-Sloan
Affiliations

Family history of cancer in benign brain tumor subtypes versus gliomas

Quinn T Ostrom et al. Front Oncol. .

Abstract

Purpose: Family history is associated with gliomas, but this association has not been established for benign brain tumors. Using information from newly diagnosed primary brain tumor patients, we describe patterns of family cancer histories in patients with benign brain tumors and compare those to patients with gliomas.

Methods: Newly diagnosed primary brain tumor patients were identified as part of the Ohio Brain Tumor Study. Each patient was asked to participate in a telephone interview about personal medical history, family history of cancer, and other exposures. Information was available from 33 acoustic neuroma (65%), 78 meningioma (65%), 49 pituitary adenoma (73.1%), and 152 glioma patients (58.2%). The association between family history of cancer and each subtype was compared with gliomas using unconditional logistic regression models generating odds ratios (ORs) and 95% confidence intervals.

Results: There was no significant difference in family history of cancer between patients with glioma and benign subtypes.

Conclusion: The results suggest that benign brain tumor may have an association with family history of cancer. More studies are warranted to disentangle the potential genetic and/or environmental causes for these diseases.

Keywords: acoustic neuroma; family history of cancer; glioma; meningioma; pituitary tumor.

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