Neurodevelopmental disorders: Glutamate blockers show benefit in models of autism spectrum disorders

Comment

Charlotte Harrison. Nat Rev Drug Discov. 2012.

. 2012 Jun 1;11(6):440-1.

doi: 10.1038/nrd3761.

No abstract available

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Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice.
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Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism.
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