Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jun;26(6):2231-7.
doi: 10.1096/fj.12-0602ufm.

DNA synthesis as a therapeutic target: the first 65 years

Christopher K Mathews  1
Affiliations

DNA synthesis as a therapeutic target: the first 65 years

Christopher K Mathews. FASEB J. 2012 Jun.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Structures of the pioneer antineoplastic drugs.
Figure 2.
Figure 2.
Titration of DHFR by aminopterin. Enzyme activity was measured as a function of enzyme concentration in the presence and absence of aminopterin as indicated (7).
Figure 3.
Figure 3.
Analysis of aminopterin binding to T4 phage DHFR by UV difference spectrophotometry. Solid line, Spectrum of 3.6 μM aminopterin in the presence of 2.8 μM DHFR versus 3.6 μM free aminopterin. Dashed line, Spectrum of 2.9 μM aminopterin at pH 2.8 versus 2.9 μM aminopterin at pH 7.0 (9).
See this image and copyright information in PMC

References

    1. Mukherjee S. (2010) The Emperor of All Maladies: A Biography of Cancer, Scribner, New York
    1. Marks P. A. (2011) The emperor of all maladies (book review). FASEB J. 25, 1786–1787
    1. Pederson T. (2011) On cancer and people (book review). Science 332, 423
    1. Osborn M. J., Freeman M., Huennekens F. M. (1958) Inhibition of dihydrofolic reductase by aminopterin and amethopterin. Proc. Soc. Exp. Biol. Med. 97, 429–431 - PubMed
    1. Cohen S. S., Flaks J. G., Barner H. D., Loeb M. R., Lichtenstein J. (1958) The mode of action of 5-fluorouracil and its derivatives. Proc. Natl. Acad. Sci. USA 44, 1004–1012 - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources