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Review
. 2012:2012:308265.
doi: 10.1100/2012/308265. Epub 2012 Apr 30.

CD8+ T cells: GITR matters

Simona Ronchetti  1 , Giuseppe Nocentini, Maria Grazia Petrillo, Carlo Riccardi
Affiliations
Review

CD8+ T cells: GITR matters

Simona Ronchetti et al. ScientificWorldJournal. 2012.

Abstract

As many members of the tumor necrosis factor receptor superfamily, glucocorticoid-induced TNFR-related gene (GITR) plays multiple roles mostly in the cells of immune system. CD8(+) T cells are key players in the immunity against viruses and tumors, and GITR has been demonstrated to be an essential molecule for these cells to mount an immune response. The aim of this paper is to focus on GITR function in CD8(+) cells, paying particular attention to numerous and recent studies that suggest its crucial role in mouse disease models.

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Figures

Figure 1
Figure 1
GITR function in antiviral immunity. Treatment with anti-GITR antibody induces activation of CD8+ cells through upregulation of GITR, release of IFN-γ, Granzyme B, and nuclear translocation of NF-κB with subsequent transcription of target genes. GITRL is expressed in dendritic cells.
Figure 2
Figure 2
GITR function in antitumoral immunity. Treatment with anti-GITR antibody and GITRL recombinant protein induces activation of CD8+ cells through upregulation of GITR, release of IFN-γ  and Granzyme B. There is evidence that some tumors express GITRL.
See this image and copyright information in PMC

References

    1. Nocentini G, Ronchetti S, Petrillo MG, Riccardi C. Pharmacological modulation of GITRL/GITR system: therapeutic perspectives. British Journal of Pharmacology. 2012;165(7):2089–2099. - PMC - PubMed
    1. Azuma M. Role of the glucocorticoid-induced TNFR-related protein (GITR)-GITR ligand pathway in innate and adaptive immunity. Critical Reviews in Immunology. 2010;30(6):547–557. - PubMed
    1. Ronchetti S, Nocentini G, Petrillo MG, et al. Glucocorticoid-Induced TNFR family Related gene (GITR) enhances dendritic cell activity. Immunology Letters. 2011;135(1-2):24–33. - PubMed
    1. Nocentini G, Riccardi C. GITR: a modulator of immune response and inflammation. Advances in Experimental Medicine and Biology. 2009;647:156–173. - PubMed
    1. Nocentini G, Ronchetti S, Bartoli A, et al. Identification of three novel mRNA splice variants of GITR. Cell Death and Differentiation. 2000;7(4):408–410. - PubMed

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