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. 2012 Jun 20;134(24):9902-5.
doi: 10.1021/ja3036459. Epub 2012 Jun 6.

Palladium-catalyzed oxidative carbonylation of benzylic C-H bonds via nondirected C(sp3)-H activation

Pan Xie  1 , Yinjun Xie, Bo Qian, Han Zhou, Chungu Xia, Hanmin Huang
Affiliations

Palladium-catalyzed oxidative carbonylation of benzylic C-H bonds via nondirected C(sp3)-H activation

Pan Xie et al. J Am Chem Soc. .

Abstract

A new strategy for generating benzylpalladium reactive species from toluenes via nondirected C(sp(3))-H activation has been developed. This led to construction of an efficient Pd-catalyzed reaction protocol for the oxidative carboxylation of benzylic C-H bonds to form substituted 2-phenylacetic acid esters and derivatives from inexpensive, commercially available starting materials.

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