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. 2013 Jan-Feb;54(1):67-73.
doi: 10.1016/j.psym.2012.03.001. Epub 2012 Jun 2.

Obese schizophrenia spectrum patients have significantly higher 10-year general cardiovascular risk and vascular ages than obese individuals without severe mental illness

Joseph C Ratliff  1 , Laura B Palmese, Erin L Reutenauer, Vinod H Srihari, Cenk Tek
Affiliations

Obese schizophrenia spectrum patients have significantly higher 10-year general cardiovascular risk and vascular ages than obese individuals without severe mental illness

Joseph C Ratliff et al. Psychosomatics. 2013 Jan-Feb.

Abstract

Background: Individuals with schizophrenia have a life expectancy that is 20 years less than the general population, along with high rates of obesity and cardiovascular disease (CVD) mortality.

Objective: This study assessed the 10-year general CVD risk and vascular ages of 106 obese schizophrenia spectrum patients and 197 demographically matched obese controls without severe mental illness (SMI) from the National Health and Nutrition Examination Survey (NHANES).

Methods: Vascular age and general CVD risk were calculated using the Framingham global CVD calculator, which incorporates age, sex, total and HDL cholesterol levels, systolic blood pressure, smoking status, and diabetes or hypertension treatment.

Results: Obese schizophrenia spectrum patients had a mean vascular age that was 14.1 years older than their mean actual age, whereas obese NHANES participants had only a 6.7-year difference. The probability of experiencing a CVD event within the next 10 years was 10.7% for obese patients and 8.5% for obese NHANES participants.

Conclusion: These findings suggest that schizophrenia spectrum patients experience increased metabolic risk independent of weight. Primary care clinicians can utilize general CVD risk and vascular age scores to communicate metabolic risk more easily and to help make treatment decisions.

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Figures

Figure 1
Figure 1. Probability of a CVD event in 10 years
Abbreviations: SP, schizophrenia spectrum patients. Normal reference percentage was calculated using values for a 47 year old female with no risk factors (systolic blood pressure = 125 mmHg, total cholesterol level = 180 mg/dl, and HDL cholesterol level = 45 mg/dl).
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References

    1. Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, et al. Heart Disease and Stroke Statistics—2011 Update. Circulation. 2011 Feb 1;123(4):e18–e209. - PMC - PubMed
    1. Jackson R, Lawes CMM, Bennett DA, Milne RJ, Rodgers A. Treatment with drugs to lower blood pressure and blood cholesterol based on an individual’s absolute cardiovascular risk. Lancet. 2005 Feb 29;365(9457):434–41. - PubMed
    1. Cleeman JI. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) JAMA. 2001;285(19):2486–97. - PubMed
    1. Ridker PM, Buring JE, Rifai N, Cook NR. Development and Validation of Improved Algorithms for the Assessment of Global Cardiovascular Risk in Women. JAMA. 2007 Feb 14;297(6):611–619. - PubMed
    1. Hippisley-Cox J, Coupland C, Vinogradova Y, Robson J, May M, Brindle P. Derivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort study. BMJ. 2007 Jul 21;335(7611):136. - PMC - PubMed

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