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Review
. 2012 Jun 5;19(6):560-7.
doi: 10.1038/nsmb.2313.

One core, two shells: bacterial and eukaryotic ribosomes

Sergey Melnikov  1 , Adam Ben-Shem, Nicolas Garreau de Loubresse, Lasse Jenner, Gulnara Yusupova, Marat Yusupov
Affiliations
Review

One core, two shells: bacterial and eukaryotic ribosomes

Sergey Melnikov et al. Nat Struct Mol Biol. .

Abstract

Ribosomes are universally conserved enzymes that carry out protein biosynthesis. Bacterial and eukaryotic ribosomes, which share an evolutionarily conserved core, are thought to have evolved from a common ancestor by addition of proteins and RNA that bestow different functionalities to ribosomes from different domains of life. Recently, structures of the eukaryotic ribosome, determined by X-ray crystallography, have allowed us to compare these structures to previously determined structures of bacterial ribosomes. Here we describe selected bacteria- or eukaryote-specific structural features of the ribosome and discuss the functional implications of some of them.

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