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Randomized Controlled Trial
. 2012 Jun 1;166(6):551-7.
doi: 10.1001/archpediatrics.2011.900.

Staphylococcus aureus colonization in children with community-associated Staphylococcus aureus skin infections and their household contacts

Stephanie A Fritz  1 , Patrick G Hogan, Genevieve Hayek, Kimberly A Eisenstein, Marcela Rodriguez, Melissa Krauss, Jane Garbutt, Victoria J Fraser
Affiliations
Randomized Controlled Trial

Staphylococcus aureus colonization in children with community-associated Staphylococcus aureus skin infections and their household contacts

Stephanie A Fritz et al. Arch Pediatr Adolesc Med. .

Abstract

Objectives: To measure prevalence of Staphylococcus aureus colonization in household contacts of children with acute S aureus skin and soft tissue infections (SSTI), determine risk factors for S aureus colonization in household contacts, and assess anatomic sites of S aureus colonization in patients and household contacts.

Design: Cross-sectional study.

Setting: St Louis Children's Hospital Emergency Department and ambulatory wound center and 9 community pediatric practices affiliated with a practice-based research network.

Participants: Patients with community-associated S aureus SSTI and S aureus colonization (in the nose, axilla, and/or inguinal folds) and their household contacts.

Outcome measures: Colonization of household contacts of pediatric patients with S aureus colonization and SSTI.

Results: Of 183 index patients, 112 (61%) were colonized with methicillin-resistant S aureus (MRSA); 54 (30%), with methicillin-sensitive S aureus (MSSA); and 17 (9%), with both MRSA and MSSA. Of 609 household contacts, 323 (53%) were colonized with S aureus: 115 (19%) with MRSA, 195 (32%) with MSSA, and 13 (2%) with both. Parents were more likely than other household contacts to be colonized with MRSA (odds ratio, 1.72; 95% CI, 1.12 to 2.63). Methicillin-resistant S aureus colonized the inguinal folds more frequently than MSSA (odds ratio, 1.67; 95% CI, 1.16 to 2.41), and MSSA colonized the nose more frequently than MRSA (odds ratio, 1.75; 95% CI, 1.19 to 2.56).

Conclusions: Household contacts of children with S aureus SSTI had a high rate of MRSA colonization compared with the general population. The inguinal fold is a prominent site of MRSA colonization, which may be an important consideration for active surveillance programs in hospitals.

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Figures

Figure 1
Figure 1
Proportion of household contacts (N=609) colonized with MRSA or MSSA by index patient (N=162) colonization with MRSA or MSSA. The analysis excluded 17 index patients colonized with both MRSA and MSSA and 4 patients for whom household colonization information was not available.
See this image and copyright information in PMC

References

    1. Osterlund A, Kahlmeter G, Bieber L, Runehagen A, Breider JM. Intrafamilial spread of highly virulent Staphylococcus aureus strains carrying the gene for Panton-Valentine leukocidin. Scand J Infect Dis. 2002;34(10):763–764. - PubMed
    1. Jones TF, Creech CB, Erwin P, Baird SG, Woron AM, Schaffner W. Family outbreaks of invasive community-associated methicillin-resistant Staphylococcus aureus infection. Clin Infect Dis. 2006;42(9):e76–e78. - PubMed
    1. L'Heriteau F, Lucet JC, Scanvic A, Bouvet E. Community-acquired methicillin-resistant Staphylococcus aureus and familial transmission. JAMA. 1999;282(11):1038–1039. - PubMed
    1. Huijsdens XW, van Santen-Verheuvel MG, Spalburg E, et al. Multiple cases of familial transmission of community-acquired methicillin-resistant Staphylococcus aureus . J Clin Microbiol. 2006;44(8):2994–2996. - PMC - PubMed
    1. Johansson PJ, Gustafsson EB, Ringberg H. High prevalence of MRSA in household contacts. Scand J Infect Dis. 2007;39(9):764–768. - PubMed

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