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. 2012:2012:608732.
doi: 10.1155/2012/608732. Epub 2012 May 14.

Traumatic brain injury, microglia, and Beta amyloid

Rebekah C Mannix  1 , Michael J Whalen
Affiliations

Traumatic brain injury, microglia, and Beta amyloid

Rebekah C Mannix et al. Int J Alzheimers Dis. 2012.

Abstract

Recently, there has been growing interest in the association between traumatic brain injury (TBI) and Alzheimer's Disease (AD). TBI and AD share many pathologic features including chronic inflammation and the accumulation of beta amyloid (Aβ). Data from both AD and TBI studies suggest that microglia play a central role in Aβ accumulation after TBI. This paper focuses on the current research on the role of microglia response to Aβ after TBI.

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Figures

Figure 1
Figure 1
Schematic depiction of the beneficial and detrimental effects of the interaction Aβ -genesis and microglia after traumatic brain injury.
See this image and copyright information in PMC

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