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. 2009 Sep;1(4):169-78.
doi: 10.4297/najms.2009.4169.

A new variant of endemic pemphigus foliaceus in El-Bagre, Colombia: the Hardy-Weinberg-Castle law and linked short tandem repeats

Ana María Abreu-Velez  1 , Edinson Villa Robles, Michael S Howard
Affiliations

A new variant of endemic pemphigus foliaceus in El-Bagre, Colombia: the Hardy-Weinberg-Castle law and linked short tandem repeats

Ana María Abreu-Velez et al. N Am J Med Sci. 2009 Sep.

Abstract

Background: We reported a new variant of endemic pemphigus foliaceus in El Bagre, Colombia.

Aims: Our study performed Complex Segregation Analysis (CSA) and short tandem repeats to discriminate between environmental and/or genetic factors in this disorder.

Materials and methods: The CSA analysis was carried out according to the unified model, implemented using the transmission probabilities implemented in the computer program POINTER, and evaluated by using a software package for population genetic data analysis (GDA), Arlequin. We performed pedigree analyses by using Cyrillic 2.1 software, with a total of 30 families with 50 probands (47 males and 3 females) tested. In parallel to the CSA, we tested for the presence of short tandem repeats from HLA class II, DQ alpha 1, involving the gene locus D6S291 by using the Hardy-Weinberg- Castle law.

Results: Our results indicate that the best model of inheritance in this disease is a mixed model, with multifactorial effects within a recessive genotype. Two types of possible segregation patterns were found; one with strong recessive penetrance in families whose phenotype is more Amerindian-like, and another of possible somatic mutations.

Conclusion: The penetrance of 10% or less in female patients 60 years of age or older indicates that hormones could protect younger females. The greatest risk factor for men being affected by the disorder was the NN genotype. These findings are only possible due to somatic mutations, and/or strong environmental effects. We also found a protective role for two genetic loci (D6S1019 AND D6S439) in the control group.

Keywords: Endemic pemphigus foliaceus; complex segregation analysis (CSA); short tandem repeats (STRs).

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Figures

Figure 1
Figure 1
A: shows the penetrance for males (affection/genotype by sex) in people affected by El Bagre-EPF. B. Shows the penetrance for males (affection/genotype by sex) in people affected by El Bagre-EPF. C. Shows the risk for males for developing El Bagre-EPF (affection/genotype by sex). D. Shows the risk for females for developing El Bagre-EPF (affection/genotype by sex).
See this image and copyright information in PMC

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