Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2012 Jun;113(6):799-807.
doi: 10.1016/j.oooo.2012.01.027.

An evaluation of the Shandon Papspin liquid-based oral test using a novel cytologic scoring system

Amir Afrogheh  1 , Colleen Anne Wright, Sean Liam Sellars, Julie Wetter, Andrew Pelser, Pawel Tomasz Schubert, Jos Hille
Affiliations
Comparative Study

An evaluation of the Shandon Papspin liquid-based oral test using a novel cytologic scoring system

Amir Afrogheh et al. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Jun.

Abstract

Objectives: The aim of this study was to evaluate a cost-effective oral liquid-based cytology screening test, Shandon Papspin (PS).

Study design: We compared the diagnostic accuracy of PS with surgical biopsy in 69 patients. Transepithelial cytology specimens were obtained with the use of cervical cytobrushes. Cytology specimens were graded and scored by using a novel oral cytologic grading and scoring system.

Results: Histologic diagnosis of dysplasia or malignancy was made in 51/69 cases, and cytology identified 49/51 cases, with a sensitivity of 96% and specificity of 100%. The best cutoff value for distinguishing reactive/mildly dysplastic lesions from high grade/invasive squamous cell carcinoma was determined to be a cytologic score of 3, representing a sensitivity of 95% and specificity of 96%.

Conclusions: PS appears to be an accurate and economical test for detection of high-risk dysplasias and cancers, but the real significance of this method will be its diagnostic accuracy in studies focusing strictly on lesions with a low level of clinical concern.

PubMed Disclaimer

Substances