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Case Reports
. 2011 Dec 2:2011:bcr0620114392.
doi: 10.1136/bcr.06.2011.4392.

Pulmonary extramedullary haematopoiesis

Veenu Mubarak  1 , Stephen Fanning, Morgon Windsor, Edwina Duhig, Simon Bowler
Affiliations
Case Reports

Pulmonary extramedullary haematopoiesis

Veenu Mubarak et al. BMJ Case Rep. .

Abstract

A 72-year-old Caucasian lady with myeloproliferative disorder was admitted for evaluation of progressive dyspnoea, weight loss, fatigue and mild hypoxia. A diffuse ground glass opacity was seen on CT pulmonary angiogram. Differential diagnoses included heart failure, infection, progression of myeloproliferative disorder with extramedullary haematopoiesis, thromboembolism or hydroxyurea-induced lung injury. Bronchoscopy and broncho-alveolar lavage were uninformative however lung biopsy with video-assisted thoracoscopy revealed extramedullary haematopoiesis within lung parenchyma. This is a very rare complication of myeloproliferative disorder and the authors discuss the significance of the case, review the literature and report the patient's progress.

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Conflict of interest statement

Competing interests None.

Figures

Figure 1
Figure 1
CT chest – bilateral ground glass appearance at mid thoracic section.
Figure 2
Figure 2
Histopathology of lung biopsy specimen – atypical cellular infiltrates showing features of myeloid origin.
Figure 3
Figure 3
Immunohistochemistry of lung biopsy specimen with lysozyme stain which picked up myeloid cells.
Figure 4
Figure 4
Immunohistochemistry of lung biopsy specimen with myeloperoxidase stain picked up myeloid cells.
See this image and copyright information in PMC

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