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Editorial
. 2012 Jun;141(6):1379-1382.
doi: 10.1378/chest.12-0155.

Point: should positive end-expiratory pressure in patients with ARDS be set on oxygenation? Yes

Russell R Miller 3rd  1 , Neil R MacIntyre  2 , R Duncan Hite  3 , Jonathon D Truwit  4 , Roy G Brower  5 , Alan H Morris  6
Affiliations
Editorial

Point: should positive end-expiratory pressure in patients with ARDS be set on oxygenation? Yes

Russell R Miller 3rd et al. Chest. 2012 Jun.
No abstract available

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Conflict of interest statement

Financial/nonfinancial disclosures: The authors have reported to CHEST the following conflicts of interest: Dr MacIntyre has been a consultant for CareFusion Corporation since 1985. Dr Hite currently is a National Institutes of Health-funded investigator for studies related to ARDS. He also serves as a consultant (data safety and monitoring board chair) for a clinical trial sponsored by Cumberland Pharmaceuticals Inc and is a shareholder in Discovery Laboratories, Inc (both unrelated to the content of this article). Dr Hite has been an unfunded speaker on the subject of mechanical ventilation and ARDS, which is relevant to the content of this article. Dr Truwit has received National Institutes of Health grant funding in ARDS and an ARDS-surfactant grant from PneumoPartners. Drs Miller, Brower, and Morris have reported that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Figures

Figure 1.
Figure 1.
The inspiratory limb of the pressure (x-axis)-volume (y-axis) curve is characteristically sigmoid. Along the continuum of increasing pressure and volume (a-c), alveoli (represented by ovals and circles) progressively distend. Below the lower inflection point (a), increased pressure may recruit airless alveoli. Between the lower and upper inflection points (b), open alveoli distend with increased pressure. Above the upper inflection point (c), alveoli may overdistend with increased pressure and become injured (indicated by the dashed line).
See this image and copyright information in PMC

Comment in

References

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