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. 2012 May;53(5):297-303.
doi: 10.4111/kju.2012.53.5.297. Epub 2012 May 18.

High-grade prostatic intraepithelial neoplasia

Joseph C Klink  1 , Ranko Miocinovic, Cristina Magi Galluzzi, Eric A Klein
Affiliations

High-grade prostatic intraepithelial neoplasia

Joseph C Klink et al. Korean J Urol. 2012 May.

Abstract

High-grade prostatic intraepithelial neoplasia (HGPIN) has been established as a precursor to prostatic adenocarcinoma. HGPIN shares many morphological, genetic, and molecular signatures with prostate cancer. Its predictive value for the development of future adenocarcinoma during the prostate-specific antigen screening era has decreased, mostly owing to the increase in prostate biopsy cores. Nevertheless, a literature review supports that large-volume HGPIN and multiple cores of involvement at the initial biopsy should prompt a repeat biopsy of the prostate within 1 year. No treatment is recommended for HGPIN to slow its progression to cancer.

Keywords: HGPIN; High grade prostatic intraepithelial neoplasia; Prostate biopsy; Prostate cancer.

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Conflict of interest statement

The authors have nothing to disclose.

Figures

FIG. 1
FIG. 1
Prostatic gland with HGPIN (right) and normal prostatic gland (left). Note the preserved architecture of the gland involved by HGPIN and largely intact basal cell layer (H&E, ×20). HGPIN, high-grade prostatic intraepithelial neoplasia.
FIG. 2
FIG. 2
High-power view of prostatic gland with HGPIN showing enlarged secretory cells with increased nuclear/cytoplasmic ratio and prominent nucleoli. Note the partially disrupted basal cell layer (H&E, ×40). HGPIN, high-grade prostatic intraepithelial neoplasia.
See this image and copyright information in PMC

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