Review
doi: 10.1111/j.1742-4658.2012.08651.x.
Epub 2012 Jul 3.
Normal and cancer cell metabolism: lymphocytes and lymphoma
Affiliations
- PMID: 22672505
- DOI: 10.1111/j.1742-4658.2012.08651.x
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Review
Normal and cancer cell metabolism: lymphocytes and lymphoma
FEBS J.
2012 Aug.
Free article
Abstract
Recent studies of normal and neoplastic lymphocytes have revealed overlapping metabolic rewiring in activated T cells and Myc-transformed lymphocytes. Myc expression is attenuated in normal lymphocytes that return to the basal state, but Notch-activated or Myc-transformed lymphocytes persistently express Myc, which activates genes involved in glucose and glutamine metabolism. Although this difference could provide a therapeutic window for the treatment of cancers, the overlapping metabolic profiles suggest a potential for immunosuppression by metabolic inhibitors.
© 2012 The Authors Journal compilation © 2012 FEBS.
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