Cancers co-opt cohabitants' catabolism: autophagy and senescence in the tumor stroma

Comment

Ben J E Zealley et al. Cell Cycle. 2012.

. 2012 Jun 15;11(12):2230-1.

doi: 10.4161/cc.20964. Epub 2012 Jun 15.

Abstract

Comment on: Capparelli C, et al. Cell Cycle 2012; 11:2272-84 and Capparelli C, et al. Cell Cycle 2012; 11:2285-302.

Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production.
Capparelli C, Guido C, Whitaker-Menezes D, Bonuccelli G, Balliet R, Pestell TG, Goldberg AF, Pestell RG, Howell A, Sneddon S, Birbe R, Tsirigos A, Martinez-Outschoorn U, Sotgia F, Lisanti MP. Capparelli C, et al. Cell Cycle. 2012 Jun 15;11(12):2285-302. doi: 10.4161/cc.20718. Epub 2012 Jun 15. Cell Cycle. 2012. PMID: 22684298 Free PMC article.
CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth.
Capparelli C, Whitaker-Menezes D, Guido C, Balliet R, Pestell TG, Howell A, Sneddon S, Pestell RG, Martinez-Outschoorn U, Lisanti MP, Sotgia F. Capparelli C, et al. Cell Cycle. 2012 Jun 15;11(12):2272-84. doi: 10.4161/cc.20717. Epub 2012 Jun 15. Cell Cycle. 2012. PMID: 22684333 Free PMC article.

1. Young AR, et al. Genes Dev. 2009;23:798–803. doi: 10.1101/gad.519709. - DOI - PMC - PubMed
1. Capparelli C, et al. Cell Cycle. 2012 doi: 10.4161/cc.20717. In press. - DOI
1. Capparelli C, et al. Cell Cycle. 2010 doi: 10.4161/cc.20718. In press. - DOI
1. Le Lay S, et al. Autophagy. 2010;6:754–63. doi: 10.4161/auto.6.6.12574. - DOI - PubMed
1. Jeyapalan JC, et al. Mech Ageing Dev. 2008;129:467–74. doi: 10.1016/j.mad.2008.04.001. - DOI - PMC - PubMed