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Comparative Study
. 2013 Feb;80(2):97-101.
doi: 10.1007/s12098-012-0784-y. Epub 2012 Jun 7.

Clinical features of severe influenza A (H1N1) virus infection

Yinghu Chen  1 , Shiqiang Shang, Yongmin Tang, Chenmei Zhang, Meiqin Tong, Yuwen Dai
Affiliations
Comparative Study

Clinical features of severe influenza A (H1N1) virus infection

Yinghu Chen et al. Indian J Pediatr. 2013 Feb.

Abstract

Objective: To highlight the clinical presentations of influenza A (H1N1) infection, for early diagnosis and recognition by the pediatricians.

Methods: In this retrospective study, the medical records of inpatients with influenza A (H1N1) infection between November 1, 2009 and May 31, 2011 were reviewed.

Results: Eighty pediatric in-patients with median age 41.9 mo were studied. ARDS (11/80), pneumothorax (8/80), pleural effusion (7/80) and encephalopathy (7/80) were the most frequent complications. Six of 11 ARDS patients died;all of them were under 5 y. The median days of viral shedding was 11.4 d. Slight increase of Il-6, Il-10 and TNF-γ were revealed in some cases.

Conclusions: During late stage of pandemic wave, the majority of patients were young children. Children with severe Influenza A (H1N1) are prone to develop complications, and die from ARDS. If influenza-like illness is accompanied by neurologic signs, influenza A (H1N1) virus infection should be considered. The viral shedding in children is longer than in adults.

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Figures

Fig. 1
Fig. 1
Age-specific cumulative number for confirmed hospitalized cases, by risk factors, by month age groups, from November 1, 2009–May 31, 2011 (n = 80)
See this image and copyright information in PMC

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References

    1. World Health Organization. Global Alert and Response (GAR). Pandemic (H1N1) 2009—update 111. Available from: http://www.who.int/csr/don/2010_07_30/en/index.html
    1. Tang Y, Xu X, Song H, et al. Early diagnostic and prognostic significance of a specific Th1/Th2 cytokine pattern in children with haemophagocytic syndrome. Br J Haematol. 2008;143:84–91. doi: 10.1111/j.1365-2141.2008.07298.x. - DOI - PubMed
    1. Chen Y, Qiao H, Zhang CM, Tong M, Shang S. Risk factors for prolonged shedding of 2009 H1N1 influenza virus. Indian Pediatr. 2011;48:961–3. doi: 10.1007/s13312-011-0151-5. - DOI - PubMed
    1. Li IW, Hung IF, To KK, et al. The natural viral load profile of patients with pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment. Chest. 2010;137:759–68. doi: 10.1378/chest.09-3072. - DOI - PMC - PubMed
    1. To KK, Chan KH, Li IW, et al. Viral load in patients infected with pandemic H1N1 2009 influenza A virus. J Med Virol. 2010;82:1–7. doi: 10.1002/jmv.21664. - DOI - PMC - PubMed

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