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. 2012:2012:532141.
doi: 10.1100/2012/532141. Epub 2012 May 15.

Leukoaraiosis is a chronic atherosclerotic disease

Einor Ben-Assayag  1 , Milija Mijajlovic, Shani Shenhar-Tsarfaty, Irena Bova, Ludmila Shopin, Natan M Bornstein
Affiliations

Leukoaraiosis is a chronic atherosclerotic disease

Einor Ben-Assayag et al. ScientificWorldJournal. 2012.

Abstract

Background and purpose: White matter changes (WMCs), or leukoaraiosis (LA), are associated with increased age, hypertension, diabetes mellitus, and history of stroke. Although several lines of evidence suggest a role of atherosclerosis in atherothrombotic vascular events, their involvement in LA remains to be determined. Our study examines this association in ischemic stroke patients.

Methods: One hundred and seventy consecutive ischemic stroke or transient ischemic attack (TIA) patients were included. All patients underwent brain computed tomography (CT) with assessment of the extension and severity of WMCs, carotid arteries duplex scan with measurements of intima-media thickness (IMT) and plaques.

Results: Seventy-two patients (42.4%) were found to have white matter lesions, of whom 28.8% had advanced LA. Mean IMT was significantly higher in patients with LA and with advanced LA (P = 0.002, P = 0.003, resp.). In addition, LA and LA severity were associated with existence of carotid plaque (P = 0.007, P = 0.004, resp.). In multivariate logistic regression analysis, including all vascular risk factors, LA was found to be associated with age and IMT.

Conclusion: This study reinforces the tight association between LA and carotid atherosclerosis in ischemic stroke patients. We conclude that a chronic atherosclerotic disease underlies the pathophysiology of leukoaraiosis and its progression.

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Figures

Figure 1
Figure 1
Two examples illustrating degrees of LA in CT scan.
Figure 2
Figure 2
Prevalence (%) of leukoaraiosis by median of intima-media thickness (IMT). *P computed by χ 2 analysis.
See this image and copyright information in PMC

References

    1. Hackinski VC, Potter P, Merskey H. Leuko-araiosis. Archives of Neurology. 1987;44(1):21–23. - PubMed
    1. Pantoni L, Garcia JH. The significance of cerebral white matter abnormalities 100 years after Binswanger’s report: A review. Stroke. 1995;26(7):1293–1301. - PubMed
    1. Liao D, Cooper L, Cai J, et al. Presence and severity of cerebral white matter lesions and hypertension, its treatment, and its control: The ARIC study. Stroke. 1996;27(12):2262–2270. - PubMed
    1. De Leeuw FE, De Groot JC, Achten E, et al. Prevalence of cerebral white matter lesions in elderly people: A population based magnetic resonance imaging study. The Rotterdam Scan Study. Journal of Neurology Neurosurgery and Psychiatry. 2001;70(1):9–14. - PMC - PubMed
    1. Pantoni L, Simoni M, Pracucci G, Schmidt R, Barkhof F, Inzitari D. Visual rating scales for age-related white matter changes (leukoaraiosis): Can the heterogeneity be reduced? Stroke. 2002;33(12):2827–2833. - PubMed

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