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. 2012 Mar;8(3):197-201.

A case of cronkhite-Canada syndrome and a review of gastrointestinal polyposis syndromes

Deepti Seshadri  1 , Nikolaos Karagiorgos, Matthew J Hyser
Affiliations

A case of cronkhite-Canada syndrome and a review of gastrointestinal polyposis syndromes

Deepti Seshadri et al. Gastroenterol Hepatol (N Y). 2012 Mar.
No abstract available

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Figures

Figure 1
Figure 1
Onychodystrophy with characteristic fingernail changes.
Figure 2
Figure 2
A diffuse carpet of polyps lining the stomach, with a similar pattern of confluent polyp formation extending into the duodenum.
Figure 3
Figure 3
Normal-appearing descending colon seen during the patient's routine surveillance colonoscopy in 2007.
Figure 4
Figure 4
The portion of the descending colon from Figure 3 seen during a routine surveillance colonoscopy in 2010 with marked interval polyp development. This endoscopic finding extended proximally to the ileocolic anastomosis and terminal ileum.
Figure 5
Figure 5
An upper gastrointestinal barium study with small bowel follow-through demonstrating multiple polyps in the stomach, duodenum, and small bowel.
Figure 6
Figure 6
Histology of gastrointestinal polyps. Both the gastric (A) and colonic (B) polyps are sessile and show hyperplastic, cystically dilated glands with edema and eosinophilic inflammation of the lamina propria (C). These composite features are most consistent with Cronkhite-Canada syndrome. (Hematoxylin and eosin stains; 40x magnification for A, 80x magnification for B, and 800x magnification for C.)
See this image and copyright information in PMC

References

    1. Cronkhite LW, Jr, Canada WJ. Generalized gastrointestinal polyposis; an unusual syndrome of polyposis, pigmentation, alopecia, and onychotrophia. N Engl J Med. 1955;252:1011–1015. - PubMed
    1. Nakamura M, Kobashikawa K, Tamura J, et al. Cronkhite-Canada syndrome. Intern Med. 2009;48:1561–1562. - PubMed
    1. Anderson RD, Patel R, Hamilton JK, Boland CR. Cronkhite-Canada syndrome presenting as eosinophilic gastroenteritis. Proc (Bayl Univ Med Cent) 2006;19:209–212. - PMC - PubMed
    1. Riegert-Johnson DL, Osborn N, Smyrk T, Boardman LA. Cronkhite-Canada syndrome hamartomatous polyps are infiltrated with IgG4 plasma cells. Digestion. 2007;75:96–97. - PubMed
    1. Calva D, Howe JR. Hamartomatous polyposis syndromes. Surg Clin North Am. 2008;88:779–817. - PMC - PubMed

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