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. 2012:2012:578373.
doi: 10.1155/2012/578373. Epub 2012 May 17.

Tau Phosphorylation by GSK3 in Different Conditions

Jesús Avila  1 , Gonzalo León-Espinosa, Esther García, Vega García-Escudero, Félix Hernández, Javier Defelipe
Affiliations

Tau Phosphorylation by GSK3 in Different Conditions

Jesús Avila et al. Int J Alzheimers Dis. 2012.

Abstract

Almost a 20% of the residues of tau protein are phosphorylatable amino acids: serine, threonine, and tyrosine. In this paper we comment on the consequences for tau of being a phosphoprotein. We will focus on serine/threonine phosphorylation. It will be discussed that, depending on the modified residue in tau molecule, phosphorylation could be protective, in processes like hibernation, or toxic like in development of those diseases known as tauopathies, which are characterized by an hyperphosphorylation and aggregation of tau.

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