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. 2012 Jun 7:5:108.
doi: 10.1186/1756-3305-5-108.

Schistosoma haematobium infections among schoolchildren in central Sudan one year after treatment with praziquantel

Abedaziz M Ahmed  1 , Hana Abbas, Fathi A Mansour, Gasim I Gasim, Ishag Adam
Affiliations

Schistosoma haematobium infections among schoolchildren in central Sudan one year after treatment with praziquantel

Abedaziz M Ahmed et al. Parasit Vectors. .

Abstract

Background: Chemotherapy with praziquantel (PZQ) is the mainstay of schistosomiasis control. However, there are recent concerns about tolerance or resistance to PZQ, so that monitoring its efficacy in different settings is required.

Methods: A longitudinal study was conducted to evaluate the impact of PZQ for the treatment of Schistosoma haematobium infection among schoolchildren at Al Salamania, Central Sudan. Parasitological examinations for S. haematobium were performed in a cohort of schoolchildren (6-15 years of age) before and 1 year after treatment with a single dose of PZQ 40 mg/kg.

Results: Out of 562 (309 boys and 253 girls) schoolchildren recruited from three elementary schools, 420 completed one longitudinal dataset that comprised of data from two time points; baseline, and follow-up 1 year after treatment with a single dose of PZQ 40 mg/kg for S. haematobium infection. A single dose of PZQ significantly reduced the prevalence of S. haematobium infection by 83.3% (from 51.4% to 8.6%) and the geometric mean intensity of infection of positive individuals by 17.0% (from 87.7 to 72.8 eggs/10 ml of urine) 1 year after treatment. While there was no significant difference in the reduction of the prevalence of S. haematobium infection between the gender or age groups, there was a significantly higher reduction of intensity of S. haematobium infection among girls in comparison with boys.

Conclusion: There was a significant reduction of S. haematobium infection 1 year after PZQ treatment in this setting.

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Figures

Figure 1
Figure 1
Map of Sudan with study area and distribution of S. haematobium and S. mansoni based on the species name in the location.
See this image and copyright information in PMC

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References

    1. Steinmann P, Keiser J, Bos R, Tanner M, Utzinger J. Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk. Lancet Infect Dis. 2006;6:411–425. doi: 10.1016/S1473-3099(06)70521-7. - DOI - PubMed
    1. WHO. WHO Technical Report Series No. 912. pp. 1–57. World Health Organization, Geneva; 2002. Prevention and control of schistosomiasis and soil-transmitted helminthiasis: Report of a WHO expert committee. - PubMed
    1. WHO. Preventive Chemotherapy Data bank. 2009. available online at: [ http://www.who.int/neglected_diseases/preventive_chemotherapy/databank/e...]
    1. Van der Werf MJ, de Vlas SJ, Brooker S, Looman CW, Nagelkerke NJ, Habbema JD, Engels D. Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa. Acta Trop. 2003;86:125–139. doi: 10.1016/S0001-706X(03)00029-9. - DOI - PubMed
    1. Mohammed EH, Eltayeb M, Ibrahim H. Haematological and biochemical morbidity of Schistosoma haematobium in school children in Sudan. Sultan Qaboos Univ Med J. 2006;6:59–64. - PMC - PubMed

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