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Comment

. 2012 Jun 26;109(26):10130-1.

doi: 10.1073/pnas.1207174109. Epub 2012 Jun 7.

Molecular basis of severe malaria

Kirk W Deitsch¹, Chetan E Chitnis

Affiliations

PMID: 22679282
PMCID: PMC3387049
DOI: 10.1073/pnas.1207174109

Comment

Molecular basis of severe malaria

Kirk W Deitsch et al. Proc Natl Acad Sci U S A. 2012.

. 2012 Jun 26;109(26):10130-1.

doi: 10.1073/pnas.1207174109. Epub 2012 Jun 7.

Authors

Kirk W Deitsch¹, Chetan E Chitnis

Affiliation

¹ Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA. kwd2001@med.cornell.edu

PMID: 22679282
PMCID: PMC3387049
DOI: 10.1073/pnas.1207174109

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1. — Fig. 1.
P. falciparum-infected erythrocytes adhere within the microcapillary beds of various tissues and organs, causing a range of symptoms and disease severity. Parasites can express different types of PfEMP1, which bind to alternative host endothelial receptors, thereby determining where in the body the infected erythrocytes sequester and the severity of disease.

See this image and copyright information in PMC

Comment on

Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children.
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A restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cells.
Avril M, Tripathi AK, Brazier AJ, Andisi C, Janes JH, Soma VL, Sullivan DJ Jr, Bull PC, Stins MF, Smith JD. Avril M, et al. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):E1782-90. doi: 10.1073/pnas.1120534109. Epub 2012 May 22. Proc Natl Acad Sci U S A. 2012. PMID: 22619321 Free PMC article.
A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells.
Claessens A, Adams Y, Ghumra A, Lindergard G, Buchan CC, Andisi C, Bull PC, Mok S, Gupta AP, Wang CW, Turner L, Arman M, Raza A, Bozdech Z, Rowe JA. Claessens A, et al. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):E1772-81. doi: 10.1073/pnas.1120461109. Epub 2012 May 22. Proc Natl Acad Sci U S A. 2012. PMID: 22619330 Free PMC article.

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References

1. Avril M, et al. A restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cells. Proc Natl Acad Sci USA. 2012;109:E1782–E1790. - PMC - PubMed
1. Claessens A, et al. A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells. Proc Natl Acad Sci USA. 2012;109:E1772–E1781. - PMC - PubMed
1. Lavstsen T, et al. Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children. Proc Natl Acad Sci USA. 2012;109:E1791–E1800. - PMC - PubMed
1. Miller LH, Baruch DI, Marsh K, Doumbo OK. The pathogenic basis of malaria. Nature. 2002;415:673–679. - PubMed
1. Baruch DI, et al. Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell. 1995;82:77–87. - PubMed

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