Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Jun 6;15(6):789-90.
doi: 10.1016/j.cmet.2012.05.004.

HOT models in flux: mitochondrial glucose oxidation fuels glioblastoma growth

Paul S Mischel  1
Affiliations
Comment

HOT models in flux: mitochondrial glucose oxidation fuels glioblastoma growth

Paul S Mischel. Cell Metab. .

Abstract

Cancer cells in culture obtain ATP and biosynthetic precursors primarily by aerobic glycolysis, not by mitochondrial glucose oxidation. In this issue of Cell Metabolism, Marin-Valencia et al. (2012) demonstrate that glioblastoma, an aggressive and, in culture, highly glycolytic cancer, primarily uses glucose oxidation to meet energetic and biosynthetic demands in vivo.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Glioblastomas in their native microenvironment primarily use mitochondrial glucose oxidation to meet energetic and biosynthetic demands
(A) When cells from a patient's brain tumor are grown in culture, glucose is primarily metabolized to lactate with minimal mitochondrial oxidation. (B) Here, Marin-Valencia et al., show that when cells from a patient's brain tumor are implanted into the brain of immunodeficient mice to simulate their native microenvironment, glioblastomas primarily utilize mitochondrial glucose oxidation.
See this image and copyright information in PMC

Comment on

References

    1. Cloughesy TF, Mischel PS. New strategies in the molecular targeting of glioblastoma: how do you hit a moving target? Clin Cancer Res. 2011;17:6–11. - PMC - PubMed
    1. Gupta PB, Fillmore CM, Jiang G, Shapira SD, Tao K, Kuperwasser C, Lander ES. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell. 2011;146:633–44. - PubMed
    1. Koppenol WH, Bounds PL, Dang CV. Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer. 2011;11:325–37. - PubMed
    1. Maher EA, Marin-Valencia I, Bachoo RM, Mashimo T, Raisanen J, Hatanpaa KJ, Jindal A, Jeffrey FM, Choi C, Madden C, Mathews D, Pascual JM, Mickey BE, Malloy CR, Deberardinis RJ. Metabolism of [U-(13)C]glucose in human brain tumors in vivo. NMR Biomed. 2012 Mar 15; 2012. doi: 10.1002/nbm.2794. - PMC - PubMed
    1. Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, et al. Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse, human glioblastomas in the mouse brain in vivo. Cell Met. 2012 this issue. - PMC - PubMed

LinkOut - more resources