Comment
doi: 10.1016/j.cmet.2012.05.006.
REV-ERBs: more than the sum of the individual parts
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- PMID: 22682217
- DOI: 10.1016/j.cmet.2012.05.006
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Comment
REV-ERBs: more than the sum of the individual parts
Cell Metab.
.
Free article
Abstract
REV-ERB nuclear receptors have been believed to stabilize the circadian clock machinery through an accessory but dispensable feedback loop. Recent work now challenges this assumption by demonstrating that REV-ERBs are essential core clock components, in addition to serving as pivotal regulators of rhythmic metabolism.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β.Nature. 2012 Mar 29;485(7396):123-7. doi: 10.1038/nature11048. Nature. 2012. PMID: 22460952 Free PMC article.
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Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function.Genes Dev. 2012 Apr 1;26(7):657-67. doi: 10.1101/gad.186858.112. Genes Dev. 2012. PMID: 22474260 Free PMC article.
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