Polarizing macrophages through reprogramming of glucose metabolism
- PMID: 22682218
- DOI: 10.1016/j.cmet.2012.05.008
Polarizing macrophages through reprogramming of glucose metabolism
Abstract
Reprogramming of intracellular metabolism is common in activated immune cells. In this issue of Cell Metabolism, Haschemi et al. (2012) show that the sedoheptulose kinase CARKL is required for metabolic reprogramming in activated macrophages and provide evidence that changes in glucose metabolism and the pentose phosphate pathway (PPP) influences macrophage polarization.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism.Cell Metab. 2012 Jun 6;15(6):813-26. doi: 10.1016/j.cmet.2012.04.023. Cell Metab. 2012. PMID: 22682222 Free PMC article.
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