Field cancerization: something new under the sun
- PMID: 22682238
- DOI: 10.1016/j.cell.2012.05.013
Field cancerization: something new under the sun
Abstract
Mutations in keratinocyte and melanocyte precursors that are caused by extensive sun exposure are well-established contributors to skin cancer. Now Hu et al. provide evidence that the sun's harmful rays may also cause tumor-promoting epigenetic modifications in dermal fibroblasts, highlighting further the importance of tumor-stroma interactions in cancer.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling.Cell. 2012 Jun 8;149(6):1207-20. doi: 10.1016/j.cell.2012.03.048. Cell. 2012. PMID: 22682244 Free PMC article.
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