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Review
. 2012 Jun 8;149(6):1192-205.
doi: 10.1016/j.cell.2012.05.012.

Wnt/β-catenin signaling and disease

Hans Clevers  1 , Roel Nusse
Affiliations
Free article
Review

Wnt/β-catenin signaling and disease

Hans Clevers et al. Cell. .
Free article

Abstract

The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.

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