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. 2012 Jun 8;6(1):53.
doi: 10.1186/1752-153X-6-53.

Quality evaluation of various commercial specifications of Polygoni Multiflori Radix and its dregs by determination of active compounds

Zhitao Liang  1 , Ngon-Ngon Leung, Hubiao Chen, Zhongzhen Zhao
Affiliations

Quality evaluation of various commercial specifications of Polygoni Multiflori Radix and its dregs by determination of active compounds

Zhitao Liang et al. Chem Cent J. .

Abstract

Background: According to market investigation, two kinds of Polygoni Multiflori Radix decoction pieces with different specifications are commercially available: irregular thick slices (0.7-1.3 cm) and length-wise into thin slices (0.11-0.2 cm). The objective of this study was to evaluate the quality of various samples of Polygoni Multiflori Radix decoction pieces and its dregs.

Results: A simple and reliable high performance liquid chromatographic method was developed for determination the contents of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D- glucopyranoside (THSG), emodin and physcion, which were considered to be potent active ingredients. The results showed that the contents of THSG, emodin and physcion varied in samples of different diameters and thicknesses. The results also indicated the dregs of Polygoni Multiflori Radix still contained a considerable amount of THSG, emodin and physcion.

Conclusion: The various commercial specifications of Polygoni Multiflori Radix sold in the markets did not correlate with their prices, and the dregs of Polygoni Multiflori Radix can be further utilized.

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Figures

Figure 1
Figure 1
The various commercial specifications of Polygoni Multiflori Radix decoction pieces in the markets (A: irregular thick slices; B. length-wise into thin slices; C. various commercial specifications in Deqing county, the numbering is consistent to Table1).
Figure 2
Figure 2
Chemical structures of active compounds. 1: 2,3,5,4′-tetrahydroxystilbene-2-O-β-D- glucopyranoside; 2: emodin; 3: physcion.
Figure 3
Figure 3
Typical HPLC chromatogram of Polygoni Multiflori Radix decoction pieces from Deqing county, Guangdong province, China. Peak1: 2,3,5,4′-tetrahydroxystilbene-2-O-β-D- glucopyranoside; Peak 2: emodin; Peak 3: physcion.
See this image and copyright information in PMC

References

    1. State Pharmacopoeia Committee. Pharmacopoeia of the People's Republic of China 2010. China Medical Science and Technology Press, Beijing; 2010. p. 164.
    1. Wei PF, Hu XQ, Yan AJ. Overview of adverse reactions caused by Polygonum multiflorum. Shaanxi J Trad Chin Med. 2004;25:170–171.
    1. Panis B, Wong DR, Hooymans PM, De Smet PA, Rosias PP. Recurrent toxic hepatitis in a Caucasian girl related to the use of Shou-Wu-Pian, a Chinese herbal preparation. J Pediatr Gastroenterol Nutr. 2005;41:256–258. doi: 10.1097/01.MPG.0000164699.41282.67. - DOI - PubMed
    1. Cárdenas A, Restrepo JC, Sierra F, Correa G. Acute hepatitis due to shen-min: a herbal product derived from Polygonum multiflorum. J Clin Gastroenterol. 2006;40:629–632. doi: 10.1097/00004836-200608000-00014. - DOI - PubMed
    1. Laird AR, Ramchandani N, DeGoma EM, Avula B, Khan IA, Gesundheit N. Acute hepatitis associated with the use of an herbal supplement mimicking iron-overload syndrome. J Clin Gastroenterol. 2008;42:861–862. doi: 10.1097/MCG.0b013e3181492515. - DOI - PubMed

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