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Review
. 2012 Jun;41(2):425-43, vii-viii.
doi: 10.1016/j.ecl.2012.04.017.

Metabolic actions of insulin-like growth factor-I in normal physiology and diabetes

David R Clemmons  1
Affiliations
Review

Metabolic actions of insulin-like growth factor-I in normal physiology and diabetes

David R Clemmons. Endocrinol Metab Clin North Am. 2012 Jun.

Abstract

Insulin-like growth factor-I (IGF-I) is closely related to insulin but has distinct metabolic actions. IGF-I is an important stimulant of protein synthesis in muscle, but it also stimulates free fatty acid use. The administration of IGF-I to patients with extreme insulin resistance results in improvement in glycemic control, and IGF-I is associated with lowering glucose and enhancing insulin sensitivity in Type 1 and Type 2 diabetes. However, patients with diabetes are also sensitive to stimulation of side effects in response to IGF-I. IGF-I coordinately links growth hormone and insulin actions and has direct effects on intermediary metabolism.

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References

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