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Review
. 2012 Dec;14(15):1377-89.
doi: 10.1016/j.micinf.2012.05.014. Epub 2012 Jun 6.

Leishmania virulence factors: focus on the metalloprotease GP63

Martin Olivier  1 , Vanessa Diniz Atayde, Amandine Isnard, Kasra Hassani, Marina Tiemi Shio
Affiliations
Free article
Review

Leishmania virulence factors: focus on the metalloprotease GP63

Martin Olivier et al. Microbes Infect. 2012 Dec.
Free article

Abstract

Parasites of Leishmania genus have developed elegant strategies permitting them to evade the innate immune response upon their initial interaction with macrophages. Their capacity to dodge the induction of macrophages microbicidal functions was found to correlate with the alteration of several signalling pathways regulating those latter. In this review, the role of the Leishmania GP63 as a critical virulence factor influencing macrophage physiology will be discussed.

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