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. 2012 Jul 18;48(56):7034-6.
doi: 10.1039/c2cc33232a. Epub 2012 Jun 11.

Mild ketone formation via Ni-catalyzed reductive coupling of unactivated alkyl halides with acid anhydrides

Hongyu Yin  1 , Chenglong Zhao, Hengzhi You, Kunhua Lin, Hegui Gong
Affiliations

Mild ketone formation via Ni-catalyzed reductive coupling of unactivated alkyl halides with acid anhydrides

Hongyu Yin et al. Chem Commun (Camb). .

Abstract

Ni-catalyzed ketone formation through mild reductive coupling of a diverse set of unactivated alkyl bromides and iodides with particularly aryl acid anhydrides was successfully developed using zinc as the terminal reductant. These conditions also allow direct coupling of alkyl iodides with aryl acids in the presence of Boc(2)O and MgCl(2).

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