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. 1990;30 Suppl 1(Suppl 1):107S-108S.
doi: 10.1111/j.1365-2125.1990.tb05476.x.

Contractions to 5-hydroxytryptamine in human coronary artery and human saphenous vein

M Borton  1 , M Neligan, F Wood, P Dervan, K Goggins, J R Docherty
Affiliations

Contractions to 5-hydroxytryptamine in human coronary artery and human saphenous vein

M Borton et al. Br J Clin Pharmacol. 1990.

Abstract

Isometric contractions were obtained to 5-hydroxytryptamine receptor agonists in human saphenous vein and human coronary artery. Based on the interaction with the 5-HT2 receptor antagonist ketanserin, both 5-HT1 and 5-HT2 receptors are involved in contractions of human saphenous vein, but the predominant subtype involved in contractions of human coronary artery is the 5-HT1 receptor.

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