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Review
. 2012 Aug;18(8):609-15.
doi: 10.1111/j.1755-5949.2012.00340.x. Epub 2012 Jun 12.

Tight junction in blood-brain barrier: an overview of structure, regulation, and regulator substances

Wei-Ye Liu  1 , Zhi-Bin Wang, Li-Chao Zhang, Xin Wei, Ling Li
Affiliations
Review

Tight junction in blood-brain barrier: an overview of structure, regulation, and regulator substances

Wei-Ye Liu et al. CNS Neurosci Ther. 2012 Aug.

Abstract

Blood-brain barrier (BBB) is a dynamic interference that regulates the nutrition and toxic substance in and out of the central nervous system (CNS), and plays a crucial role in maintaining a stable circumstance of the CNS. Tight junctions among adjacent cells form the basic structure of BBB to limiting paracellular permeability. In the present review, the constituents of tight junction proteins are depicted in detail, together with the regulation of tight junction under stimulation and in pathological conditions. Tight junction modulators are also discussed.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Molecular component of endothelial tight junctions in the BBB.
See this image and copyright information in PMC

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